User acceptance of technology is an important field of study in predicting the use of the computer systems. Unified Theory of Acceptance and Use of Technology (UTAUT) model is current model that has attracted the attention of researchers in predicting usage of computer systems. Individual performance and organizational performance can only increase by increasing user acceptance of computer systems. The research focuses on user acceptance of desktop based computer software used in organizations by adding some new moderators like gender, age, educational level, experience, individual impacts, organizational impacts and memorability to UTAUT models. The findings of study tells about the relation between the moderators and core determinants of UTAUT like Performance Expectancy, Effort Expectancy, Attitude towards using, Social influence, Facilitating conditions, Self efficacy and Anxiety. In this research, a total of 120 students of different colleges were included and four desktop based software MS-Word, Tally, Adobe Photoshop and MS-Access were analyzed. The results of study tells that performance expectancy, effort expectancy, attitude towards using and facilitating conditions are the important constructs which are useful to predict software use. The correlation analysis tells that gender, age, educational qualification, experience, individual impacts and organizational impacts has significant influence on different constructs of UTAUT model.