Psychologists have various medical ways to treat depression using counseling, medicines and much more. These ways do not guarantee that depression is totally cured. Depression affects the neurons in brain, decreasing the amount of Neurotransmitter. As neuron suspends reproduction shortly after birth thus the damaged neuron can’t be replaced, it can only be treated. Thus if the biological neurons are replaced by artificial neurons then the cure of depression would be permanent. The mathematical equations in the paper also show that the artificial neuron replacement would give a permanent cure to depression.